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KMID : 1007520020110020184
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Food Science and Biotechnology
2002 Volume.11 No. 2 p.184 ~ p.187
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Antioxidative and Free Radical Scavenging Activities of Myxochelin A Isolated from angiococcus sp. (Myxobacteria)
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Lee, Ho Hyun
Ahn, Jong Woong/Lee, Jeong Eun/Kim, Young Chan/Chung, Shin Kyo/Kwon, Joong Ho
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Abstract
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Myxochelin A, a catechole siderophore with the stricture N,N-bis-(2,3-dihydroxybenzoyl)-lysinol, was isolated from a culture broth of Angiococcus sp. As a free radical scavenger, it exhibited DPPH radical scavenging activity with an IC_50 value of 4.9㎍/mL, which is about four times more active than vitamin E (19.2㎍/mL), and was comparable with that of BHA at a concentration of 10㎍/mL in the lipid peroxidation inhibitory assay as measured by the ferric thiocyanate method. It showed strong scavenging effects of 96 and 72% at 1 and 5㎍/ mL on hydroxyl and superoxide radicals, respectively.
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